The patented ColdSafe technology works by pulling heat out of the vaccine chamber into a precisely engineered thermosyphon, which moves the heat up to the ice block. When a power source is not available, this system continues cooling the vaccines while gradually melting the ice block, without using any moving parts or electricity. ColdSafe technology has been shown to keep vaccines cold through 5 days or more, even with door openings, allowing health workers to continue to use the MetaFridge and access vaccines normally. The MetaFridge automatically creates more holdover whenever power is available, operating so efficiently that it can maintain full holdover capability with just 3 hours of power each day.
The ColdSafe thermosyphon contains a mix of liquid and vapor. The bottom of the syphon surrounds the vaccine chamber. Any excess heat in the vaccine chamber is transferred to the liquid inside the syphon. The liquid absorbs the heat, turns into vapor, and rises to the top of the thermosyphon. As the vapor rises, it is cooled by the ice block bonded to the top of the thermosyphon. The vapor condenses back into a liquid, releasing its absorbed heat to melt the ice, and the liquid falls back down towards the vaccine chamber to repeat the cycle.